Genes and drugs


Few examples:

Gene Drug(s) Histology IHC FISH mut/ins-del/transl
EGFR mut[1] erlotinib, gefitinib, afatinib AdC -/+ - +
ALK[2] crizotinib AdC + + +
cMET[3] met mab AdC, SqCC + + -
ROS1[4] crizotinib AdC +? + -
BRAF[5] sorafinib vemurafenib AdC +? - +
PIK3CA[6] everolimus temsirolimus AdC, SqCC - - +
HER2[7] trastuzumab/ lapatinib/ dacomatinib AdC + + -
EGFR ihc[8] cetuximab AdC, SqCC + +/- -
PTEN[9] everolimus temsirolimus AdC, SqCC + - -
NRAS[10] vemurafenib AdC - - +
KRAS[11] selumetinib docetaxel AdC - - +
NTRK1[12] Crizotinib (?) AdC - + +
DDR2[13] dasatinib SqCC - - +
FGFR1[14] ponatinib SqCC - + -

From European Society of Pathology http://www.esp-pathology.org/home.html